Sickle cell patients interest in traditional pharmacopoeia comes from the healing promise made by traditional practitioners and the expensive cost of medicines. The objective of this study was to evaluate the anti-sickling activity of macerated seeds of Cajanus cajan and compare its activity to that of phenylalanine. An induction of sickling due to 2% sodium metabisulfite was performed on 30 blood samples from SSFA 2 homozygous sickle cell patients. The macerated seeds of Cajanus cajan at 10 to 500 mg / ml concentrations and 10 mg / ml phenylalanine were added then. The reading was made after a contact time of 30 minutes. All extracts from the seeds of Cajanus cajan led to a reduction in the percentage of sickle cells which rose from 64.70% to 19.03%. The phenylalanine solution also caused a reduction in the percentage of sickling which rose from 64.70% to 22.76%. The activity of the maceration at the concentration of 400 mg / ml was higher than that of the phenylalanine. These results advocate for the use of Cajanus cajan seeds in the diet of sickle cell disease to reduce the occurrence of painful crisis.