Stem cell therapy presents an innovative medical intervention that can fix the damages on the human body by repairing, replacing, restoring, and regenerating the damaged tissue and organs (so called regenerative medicine) without surgery. It has been undergoing an axiological and revolutionary progress both in medical treatments (treatments for degenerative diseases, genetic disorders, damages or death of nerves and tissues / necrosis) and preventive actions such as aging prevention and reverse aging treatments. This study is library research and aims to overview such therapy from the perspectives of Indonesian law and progressive fiqh (Islamic jurisprudence). The result shows that, according to the Indonesian law and the Islamic progressive fiqh, the stem cell therapy for the treatment of degenerative diseases, genetic disorders and tissue damages or for reverse aging treatment using the cells that come from oneself (autologous) and from other people (allogeneic) is permissible, whereas if the cells come from embryonic cells, animals (xenogeneic) or plants, the Indonesian Law prohibits it while the Islamic progressive fiqh deems it permissible under strict conditions.