Introduction: The pressurized intradermotherapy is a needle-free technology whose function is the release of medicated or cosmetological actives in the skin and the subcutaneous tissue using mechanical force, gaspressure, and shockwaves, allowing the treatment of different aesthetic changes. Objective: To investigate the effects of intradermotherapy with a pressurized injection system in thetreatment of localised abdominal fat in women. Method: The sample consisted of 30 women with localized adiposity in the abdominal region, evaluated before and after treatment through evaluation protocols and ultrasound examinations. The volunteers were randomly distributed in to two subgroups: Pressurized intradermotherapy group (G01), to which were an adipolytic substance, a combination of different drugs, was applied, and the control group (CG), which received an injectable saline solution only. Both groups underwent four biweekly treatment sessions. Results: The fat layer analysis 60 days after the initial application showed a significant reduction of the measurements in the comparison between groups G01 and GC; the plicometry showed a significant difference on the right side (p = 0.04) and the left side (p = 0.04); in the supraumbilical (p = 0.001) and infra umbilical (p = 0.03) perimetries. Two months after the beginning of treatment, the ultrasound examination two showed a significant reduction on the sides: right (p = 0.03) and left (p = 0.03); however, no differences in weight were found (p>0.05). Conclusion: The treated group presented a significant fat layer reduction after the treatment with the pressurised intradermotherapy protocol, with better results after the fourth application.