Vaccination is one of the most appropriate public health intervention measures, as an indisputable means of prevention, one of the last and extensive advances in health technology in recent decades. It is a major strategy to combat and control infectious diseases in the world. This study aims to analyze parents perception of the importance of vaccinating children from 0 to 15 months in a gold mining region of the Amazon. The research was of the descriptive and exploratory type, with qualitative approach, carried out in an Edson Botelho Basic Health Unit in the city of Itaituba-Para- Brazil. Parents who attended the health unit to have their children vaccinated participated in the survey, and the sample was saturated. The collection took place by means of a semi-structured interview form, consisting of two parts: the first consisting of personal data of the research subjects and the second consisting of open questions regarding the knowledge of the importance of vaccination and guidelines they receive in the vaccination room. The data analysis was by Bardins analysis technique. The results of the survey pointed out: 15 mothers participated in the study and they consider the act of vaccinating very important, it was also evident that the children have some adverse events related to vaccination, however, the guidance of the nursing team is fundamental in the care of the vaccinated, and this reflected in the good evaluation of this team by the clients. It is concluded that mothers perceive vaccination as an important act, because they protect their children from many diseases, in addition, that in some vaccines the adverse effect is expected, however, this does not influence the practice of non-vaccination.