To establish a more comprehensive FAIR (Findable, Accessible, Interoperable, and Reusable) biomedical data ecosystem, the NIH is investigating the roles of generalist and institutional data repositories in the biomedical data repository landscape. Both generalist and institutional repositories address the needs of researchers by providing data sharing solutions when no appropriate domain-specific repositories exist. As part of the session on culture change, this presentation brings the perspective of the Neuro, the first institute to become an open science institution, as well some lessons learned from implementing an open science framework .