The content and effect of CD-57 and VEGF markers in chronic pulp lesions were studied. CD57 is an additional marker of the immune system dysfunction in chronic diseases. CD-57 is expressed on NK-cells (natural killers), some T-lymphocytes, B-lymphocytes, monocytes. Increased expression on cytotoxic lymphocytes was shown to slow down T-cells proliferation. In other words, CD57 is a antigen to natural killers. Vascular endothelial growth factors (VEGF) are powerful angiogenic factors that are produced by macrophages, fibroblasts, hepatocytes, endothelial and other cells [1]. They are involved in activation, proliferation, migration and differentiation of endothelial cells in blood and lymphatic vessels, interacting with them through specific tyrosine kinase receptors. VEGF enhances the permeability of blood vessels and creates conditions for plasma proteins to penetrate into the extracellular tissue space, promoting the migration of endothelial cells, as well as participates in regulation of cell adhesion and modulation of immune properties. Timely and accurate identification and correct interpretation of ethiopathogenetic events in endoperiodontal region, knowledge of morphology creates a strong base to refine the diagnosis and to improve the treatment of patients with endoperiodontal inflammation. The aim of the study was to assess the immunological pulp-periodontal status in patients with lesions of the endoperiodontal complex. The authors studied clinical and morphological markers CD-57 and VEGF and presented the characteristics for the expression of the markers under study. The results of the study provide morpho-functional data on the expression of these markers, which will give the opportunity to create a competent concept of the endoperiodontal complex immunological status and to contribute to improving early diagnosis and choosing an effective medical tactics. Keywords: chronic apical periodontitis, CD-57, VEGF, endoperiodontal lesions, NK-cells, immune properties, pulp, periodontium.