Background: Cancer of the oral cavity has reportedly one of the lowest survival rates, in spite of the developments in its management and treatment. Cancer treatment can have side effects that affect mouth. Working together with dentist and the doctor treating cancer may help reduce the risk and seriousness of these side effects. Objective: To evaluated the non-regulated treatment versus supervised hospital treatment on the oral health of patients undergoing oral cancer treatment Methods: A quasi-experimental study was conducted at the Oral and Maxillofacial Surgery Service of the Khulna Medical College Hospital and Different Privet Hospital in Khulna City. This study began by including patients with oral can?cer (squamous cell carcinoma) in the control group. A total of 30 patients were received from September 2017 to September 2018. After having implemented the re?sources needed to provide dental treatment, we began treating patients in the experimental group: 30 patients between October 2018 and October 2019. Results: In during and after treatment, use of chlorhexidine, use of fluoride agents and IOH and plaque control were statistically significant (p<0.05) between two group. In during treatment: plaque index, prosthesis user and daily brushing were statistically significant (p<0.05) between two group. In after treatment: plaque index, prosthesis user and daily brushing were statistically significant (p<0.05) between two group. The experimental (with dental treatment) group, plaque index was reduced by -23.93?29.90. On the other hand, the control (without dental treatment) group saw an in?crease in plaque index of +16.63?29.76 between these two periods; the difference was statistically significant (p < 0.0001). Conclusion: In conclusion, increasing daily brushing and a strong reduce in the rate of plaque in the experimental versus control groups in cancer treatment. The second part of cancer treatment saw a reduced plaque index, number of new cavities and number of extractions in the experimental group.