Background: Chronic obstructive pulmonary disease (COPD) is one of the main causes of morbidity and mortality worldwide. Because of the progressive decline in lung function, it seriously affects their quality of life and their ability to work. COPD is a chronic inflammatory disease characterized by hypercoagulation. A persistent inflammatory response can cause hypercoagulation, possibly through cytokine-induced endothelium activation or by monocyte induction to express tissue factors. D-dimers are a marker of ongoing fibrin formation and degradation. Methods: Sampling was conducted during July 2019. Total population was 56 people (29 COPD patients and 27 non-COPD patients), the entire population was examined D-dimer, Spirometry and Brinkman index, then the results were compared in both populations. The study was conducted after obtaining ethical approval and informed consent. Results: There was no difference in the Brinkman Index between the COPD and non-COPD groups with a value of p = 0.369 (p<0.05). There was a difference in FEV between the COPD and non-COPD groups with a value of p = 0,000 (p <0.05), where the COPD group had a lower FEV than the non-COPD group. There is a difference in D-Dimer levels between the COPD and non-COPD groups with a value of p = 0.003 (p <0.05). There is a difference in age between the COPD and non-COPD groups with a value of p = 0.001 (p <0.05), where the COPD group has a higher age than the non-COPD group Conclusions: Increased D-Dimer levels, in stable COPD patients, can be used to assess a prognosis and as a treatment for determining treatment in hospital.