USP5 ZnF-UBD Co-Crystal Structure with Compound UBTR012574a

Funding acknowledgement: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

Objective: To grow well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) to solve the co-crystal structures to determine ligand interactions in the binding pocket and to determine if the predicted binding pose is similar to the experimental binding pose.

Related Organizations

University of Toronto
Canada

Keywords

zinc finger, usp5, xray crystallography, co-crystal

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