The data set contains code, source data, and derivatives data for the results presented in our research paper titled "Computational analysis of mechanical stress in colonic diverticulosis". The "code" contains Abaqus (SIMULIA, Providence, RI) files for the simulations presented in the paper (tested with Abaqus version 6.13) and jupyter notebooks developed to analyze simulation results. The "sourcedata" folder contains Excel files with parameters used for the simulations as well as data directly extracted from the simulation results. The "derivatives" folder contains secondary data calculated based on the files from "sourcedata". The README document included in the dataset contains a more detailed description of the files and folders.