Natural products are the important source of bioactive compounds and have potential for the development of novel therapeutics. Natural products and their derivatives represent more than 50 % of all drugs in clinical use in the world. Herbal plants contain and produce a verity of chemical substance used as a remedy for treating diseases. Annona reticulata contain different chemical constituents. But it does not contain Glycosides, Alkloids, Phytosterols. Various drugs available in the market for nephro-protective activity and none of the drug is not up to mark for showing its efficacy. In the present examination treatment of rodents with ethanolic concentrate of underlying foundations of Annona reticulata significantly(p<0.05 in 200mg/kg b.w. what's more, p<0.01 in 400mg/kg b.w. ) diminished the degrees of SGPT in serum which means that nephrooprotective movement. SGOT is a mitochondrial catalyst discharged from heart, liver, skeletal muscle and kidney. nephro poisonous quality raised the SGOT levels in serum because of the harm to the tissues delivering intense corruption, for example, extreme viral hepatitis and intense cholestasis. Alcoholic liver harm and cirrhosis can likewise connect with gentle to direct height of transaminase. Keywords: Annona Reticulata, Gentamycin, Phytochemical screening, neproprotective activity.