~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Summary-level data as presented in: "Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure" Arvanitis et al. 2019; Preprint at: https://www.medrxiv.org/content/10.1101/19006510v2 **If you use this data please cite the above paper Marios Arvanitis marvani1@jhmi.edu ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Data files: 1. META_clean.tsv.gz Summary statistics of the Discovery GWAS meta-analysis. Max N=448,549. 2. hESC-CM_ACTN2_locus_seq.bed Bed file containing the RPKM values for ATAC-seq, H3K27ac-seq, H3K4me1-seq and RNA-seq on Days 0, 2, 5, 7, 15, 80 of cardiomyocyte differentiation from hESCs for the chromosome 1 GWAS locus near the ACTN2 gene. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Data file format: 1. META_clean.tsv.gz chrpos: SNP name in the format chromosome:position@AlleleA@AlleleB rsid: SNP name in dbSNP identifiers Allele1: Effect allele Allele2: Non-effect allele Effect: log(Odds Ratio (OR)) of Heart Failure StdErr: Standard Error of log(OR) P-value: Nominal p-value of the effect chr: SNP chromosome in hg19 pos: SNP position in hg19 Weight: Total N associated with each SNP in the meta-analysis 2. hESC-CM_ACTN2_locus_seq.bed Column 1: Chromosome in hg38 Column 2: Start position in hg38 Column 3: End position in hg38 Column 4: RPKM value Column 5: Sequencing type and day of differentiation ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~