Introduction and objective: One of the most important components of the health promotion is medication adherence and as long as the doctor prescribe the correct drugs with the correct does it will remain insufficient without medication adherence by the patient. This study main goal is to assess medication adherence in order to improve quality of life among patients who suffer from parkinsonism. Methods: a total of 43 patients are diagnosed with Parkinson's disease, who met the inclusion criteria were included in this study. We assessed their adherence to medication in in-patient neurology departments or in the out-patient clinics in Madinah -Kingdom Of Saudi Arabia. From November 2017 to June 2018 medication adherence was assessed in those particular group of patients through an interview with each patient or his/her care giver by using multiple choice graded questionnaire. Results: From a number of 43 patients, 76.8% (N = 33) of them were non-adherent to Parkinson's Disease Medications. No significant differences were found between males and females regarding there Adherence toward Parkinson's Disease Medications. A difference in adherence was noted among patients who were suffering from other comorbidities compared to patients with no other comorbidities. Forgetfulness is the most contributing factor that affect patient Adherence toward Medications. patients with higher score in beliefs about medicines questionnaire were more adherent to their management plan than patients who got lower scores and were more responsive to treatment plan.