A study was done to see the effect of progressive muscle relaxation (Jacobsons) on stress of persons with alcohol dependence syndrome at selected de-addiction centre. The objectives were 1) identify the effect of progressive muscle relaxation (Jacobsons) on stress of persons with alcohol dependence syndrome 2) explore the correlation between stress and advanced warning signs of relapse of persons with alcohol dependence syndrome. True experiential pre test post test control group design was used for 100 samples, control and experimental groups (50 each) were selected by simple random method. Structured questionnaire for personal data, perceived stress scale and Advanced Warning Signs of Relapse scale were used as tools in the study. The control and experimental groups were statistically evaluated by Friedmans Repeated Measures of ANOVA on ranks with Dunns method and Mann Whitney Rank sum test. Karl Pearsons correlation was used to correlate the parameters. The study concluded that the progressive muscle relaxation was effective for reducing stress and Advanced Warning Signs of Relapse were decreased with experimental group when stress was less and when compared to control group.