Background: Smoking in Saudi Arabia is one of the most significant health issues. The Ministry of Health worked along with other governmental institutions to decrease the impact of this problem by offering a free consultation and management at smoking cessation clinics around the country and advertise for that through different channels in media. Objectives: To estimate the success rate of smoking cessation and the factors associated with it in the Ministry of health smoking cessation program in Jeddah. Subjects and methods: A cross-sectional study among a sample of Saudi smokers attending the smoking cessation clinic in Ministry of Health primary health care centers in Jeddah city 2018 between 1st January until the 30 th June. A Self-administered validated questionnaire was utilized for data collection including two main parts; the demographic data of the participants and questions about the factors and the determinants that faced the participants in the smoking cessation process. Results: The study included 169 participants out of targeted 208 giving a response rate of 81.3%. Majority of the participants (83.4%) were current smokers and the remaining 16.6% were ex-smokers. The mean age at starting smoking is 17.7±3.8 years. Successful cessation of smoking was found among 30.8% of the respondents. More than a quarter (26.9) of those reported successful smoking trials had more than three smoking cessation trials. Regarding the reasons for smoking cessation trials, medical reasons ranked first (75%), followed by social reasons (25%). However, as regards the reasons of re-smoking after cessation, psychological reasons ranked first (63.5%), followed by social reasons (42.3%). The only significant factor with successful smoking cessation was the duration of treatment as 58.3% of participants who were treated for more than one month compared to 23.1% of those treated for a week and 5.6% of never treated participants expressed successful smoking cessation, p<0.001. Conclusion: A considerable proportion of smokers attending the smoking cessation clinic, Jeddah had a successive smoking cessation. However, most of them reported a history of re-smoking after successful smoking cessation. The reasons of re-smoking after cessation in the present study revealed that psychological reasons ranked first.