The ever-changing technological innovations disrupt lives. It affects how we deal with people or things. It Influences our feelings and emotions. It changes the way we believe in the ability, reliability, and power of something or someone. A global research on digital trust in the workplace is conducted in collaboration and partnership with schools in Asia, Latin America, Europe, and the USA. It is lodged in a university in Germany. The research is primarily aimed at measuring digital trust in the workplace with an emphasis on people, technology, and process. This paper is aimed at describing the underlying principles and theoretical underpinnings of the research “Digital Trust in the Workplace.” Specifically, it presents the framework employed in the study. Likewise, it describes each theory and principles and their relationship to each other. An Input-Process-Output model was used in the formulation of the conceptual framework of the study, which was anchored on the principles of information systems. Theories and principles included in this study are Forrester Social Technologic Ladder, Decision-making models, Technology Adoption Theory, Management Theory, Software Quality Model, General Data Protection Regulation Principles, Digital Citizenship Principles, and Caldicott Principles.