Introduction:Head and neck lesions are commonly encountered in patients of all age group including skin, soft tissue, thyroid, lymph node, salivary gland, eye, nose, oral, otologic, etc, include a spectrum of lesions ranging from simple benign to highly malignant, contribute to significant morbidity and mortility. Aims & Objective: To determine histopathological subtypes, frequency of head & neck lesion, age, gender distribution and site & organ wise distribution Methodology: A one year retrospective study was designed to study of various biopsies from head and neck region, sent for HPE at department of pathology, SSMC, Rewa, M.P. from 1st Nov 2018 to 31st Oct 2019 Result:Total 186 cases from the head and neck region were analyzed .Age range was 4 years to 89 years. With maximum cases were in the age group of 11-30 years (60.2%).M:F ratio was 1.16:1. In our study, 55.9% benign, 33.3% inflammatory,6.5% malignant lesion. Squamous cell carcinoma was the most common malignant lesion Conclusion:We conclude that site specific data like this is helpful in evaluating patterns of head and neck lesions and augment the baseline data of institute and region.