Klaibya is a multi-factorial condition, mainly involving Bahu Doshavastha as a whole and Sukrakhsaya in specific, Mano Dosa, and Sukravaha Sroto Dusti. The term Klaibya is known as Erectile dysfunction (E.D.) in modern texts. The male sexual dysfunction includes all sorts of disturbances of coital performance and sexual congress in male. Among the various phases of sexual response the most essential is the intercourse, the absence of which ends into failure and dissatisfaction. Main aim of present study was to comparatively assess the efficacy of Amalaka Yoga and Ashwini Mudra in the patients of Klaibya. For the above purpose 60 patients were selected and randomly divided into two groups, each group had been 30 patients. It can be concluded that the Klaibya can be better managed by administration of Ashwini Mudra.