The world of mobile wireless communication is rapidly developing. The last few years have experience a remarkable growth in wireless industry. Just within a decade, an evolution of wireless service people used every day can be completely dumbfounded from the roots of analog based first generation service 1G to today's truly broadband ready fourth generation networks. The ever growing demands for higher data rates, greater capacity and better quality of services triggered operations to come up with new network technologies. There are many improvements of mobile generations in the world of telecommunication. Mobile Switching Center can perform various types of function in mobile communication. It also connects VLR Visitor Location Register , HLR Home Location Register , AuC Authentication Center and EIR Equipment Identity Register and they are essential needing for mobile communication. This paper represents the introduction about evolution from 1G to 4G system and discusses about the main elements in Mobile Switching Center eventually it includes comparison of Mobile Switching Center in every mobile generations. Aye Myat Myat Myo | Zar Chi Soe "Comparative Study on Mobile Switching Center of Mobile Generations" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26643.pdf