Introduction: Allergic rhinitis (AR) is an allergic disease mediated by IgE, which is increasing in incidence. Aims and objectives: The basic aim of the study is to analyse the efficacy of cluster and conventional immunotherapy in patients with allergic rhinitis. Material and methods: This cross sectional study was conducted in Mohi ud Din Islamic Medical College, Mirpur during January 2019 to July 2019. The data was collected from both male and female patients who visited the OPD of the hospital. All patients underwent a skin prick test (SPT) using histamine (positive control) and standard extracts. Results: The data was collected from 60 patients. Among the 60 patients enrolled in the present study, 57 completed follow-up: cluster immunotherapy group (n=28) and conventional immunotherapy group (n=29). Two out of the three cases lost to follow-up were from the cluster immunotherapy group, and the remaining case was from the conventional group. These results demonstrated that the effective rate after 6 months of treatment was less than that after 6 weeks in the cluster group. Conclusion: It is concluded that cluster immunotherapy is able to improve symptoms in patients with AR caused by dust mites, with no increase in adverse reactions. Therefore, cluster immunotherapy may be a rapid, effective, safe treatment for moderate to severe persistent AR.