Supplementary Materials Figure S1. PI resistance is reversible in MLL cells. Figure S2. PI-treated cell-derived exosomes induce cell cycle arrest and PI resistance in SEM cells. Figure S3. Unsupervised hierarchical clustering heatmap of differentially expressed proteins in RS4;11-Nexo- or RS4;11-Rexo-treated RS4;11 cells. Figure S4. Integrated network nodes and edges related to “upstream” exosomal proteins. Figure S5. Integrated network nodes and edges related to “downstream” genes in the transcriptome profile of recipient cells. Figure S6. Potential therapeutic targets related to exosomal regulatory proteins. Figure S7. TieDIE integration network nodes and edges related to the cell cycle pathway. Figure S8. TieDIE integration network nodes and edges related to the stemness pathway. Figure S9. The original western blot images in this manuscript. Table S1. Differentially expressed proteins in exosomes. Table S2. Nodes of the TieDIE integrated network. Table S3. The exosomal regulatory proteins and the corresponding drugs or compounds.