Tuberculosis (TB) is an endemic disease that produces high morbidity and mortality among humans in the world. Diabetes mellitus (DM) increases the risk of contracting TB from diabetes patients compared to the general population. Objective: The aim of this analysis was to know the prevalence of TB in patients receiving medication for DM. Study Design: A cross-sectional study. Place and Duration: In the Medicine unit of Hospital of Zhengzhou University China for three months duration from March 2019 to May 2019. Methods: The study included all patients aged 18-60 years with a diagnosis of DM who were admitted to the diabetes clinic currently under treatment. All patients were asked for symptoms of tuberculosis. If TB symptoms were positive, sputum analysis was performed. Three sputum samples (morning spot) were collected to observe AFB. Data were analysed with SPSS version 20. Results: A total of 290 patients were included in the study. The mean age of the patients was 45.63 ± 10.33 years. Among these, 172 patients (59.3%) were women. In addition, 63 patients (21.7%) had type 1 DM and 227 patients (78.3%) had type 2 DM. When asked questions about tuberculosis symptoms, 32 patients (11.0%) were positive. The remaining 258 patients were negative (89%). However, an additional sputum analysis showed that TB was confirmed in only 12 patients (4.1%). After adjustment of the confounding factors, age, sex and type of DM did not appear to play an important role in the development of tuberculosis in these patients. Conclusion: As in this study, we recommend that regular screening of all diabetic patients in our country should be considered endemic for this fatal disease in relation to the high prevalence of TB in diabetic patients. Keywords: Diabetes Mellitus, prevalence, tuberculosis.