Objectives: Crystals of calcium oxalate are the most widely recognized kind of kidney stones. Kidney stones are dense masses that form in the kidney when there are increased levels of calcium, oxalate, cystine, or phosphate and very less liquid. The basic aim of the study is to analyze the use of probiotics supplements for the management of calcium oxalate kidney Stone in local population of Pakistan. Methodology: This study was conducted at health department Punjab during 2019. This was basically a preliminary study which was conducted for the awareness of those patients who are suffering from kidney stones. Results: Not all of the research is in support of the benefit provided by these supplements, and it is important to be aware of the associated risks and benefi ts. In nephrology, these supplements show potential benefi ts in treating kidney stones, uremia, and urinary tract infections. Conclusion: It is concluded that some evidence has supported the use of prebiotics, probiotics, or synbiotics, especially for the treatment of diarrhea, their use in other disease states is controversial. Special caution needs to be exercised when using these supplements in the immune compromised and the acutely ill, as serious and potentially fatal complications have recently been reported.