Gestational trophoblastic diseases comprise benign entities called hydatiform moles (HM), which could be complete or partial moles, and malignant entities called gestational trophoblastic tumors (GTT) which include some invasive moles, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. GTTs most common form is the invasive mole, diagnosed when cancer is still confined to the uterus in most cases, while choriocarcinoma is the rarest form leading to distant metastases. GTTs therapeutic protocol implementation requires a locoregional and distant staging in order to find the appropriate protocol. Through this work, we present you with a case report of a patient with cerebral metastasis revealing a GTT, and her care management in our department.