Scrub Thypus is a disease caused by a bacteria called Orentia Tsutsugamashi.It spreads through bites of infected chiggers and presented with acute febrile illness ; Headache,Body aches ,pain abdomen and sometimes with rashes. It is endemic to east and south east Asia and northern Australia and Indian Ocean. Nowadays Its cases are increasing in this region due to good diagnostic approach and high index of clinical suspicion and treated if detected early, serologically ,because almost no body have pathognomic eschar. Objective:- To study the clinical presentation and its biochemical changes in District hospital chittorgarh during the period of May 2019 to September 2019. Methods:- This is a urban rural based study of 100 patients with fever and pain abdomen, diagnosed as scrub typhus at district hospital chittorgarh. Results:- 100 patients between the age of 15-70 yrs presented with fever ,pain abdomen,nausea , vomiting and headache.In investigations ,lab findings Showed low platelets, low WBC. ,increased SGOT, SGPT ,.Few of them are with complication like acute renal failure,minimal ascities,multiple organ dysfunction and meningial signs .Diagnosis was confirmed by immunochromatography that is card test for IgM antibodies and ELISA. Out of 100 patients 80% patients were recovered with in 3to 4 days and only 4% had complication were reffered to higher center .,no death occurred.