Ashmari is one of the disorders of Mutravaha Srotas and one among the Astamahagada. Mutrashmari is a formation of stone anywhere in the Mutravaha Srotas, which can be correlated with Urinary tract stone or urolithiasis. Renal calculi are one of the most painful and common disorders of urinary tract. As Ashmari is Kapha Pradhana Tridoshaja Vyadhi. As Kshara is Tridoshaghna it is indicated in Mutrashamri. Varunaksharadi Yoga mentioned in Vangasena in Ashmari Rogadhikara. The case study taken on Mutrashmari. A male patient aged 35 years having complaint of Right side pain abdomen since 15 days. This case study shows that Varunaksharadi Yoga having good result in treating Mutrashamari. The formulation is having Ashmari Chedana, Bhedana and processes Mutrala properties. As per classics Ashmari is Tridoshaja Vyadhi and Kshara is having Tridoshghna property so it plays an important role in SampraptiVighatana in Mutrashmari.