Aim:Paracetamol (PCM) overdose induces Hepatotoxicity in humans and experimental animals. The present study aims to evaluate Hepatoprotective activity of Schisandra grandiflora against paracetamol induced hepatotoxicity. Method: In this experimental study wistar albino Rats were selected and Hepatotoxicity induced by paracetamol (PCM) p.o, 3g/kg body weight. On 7th day after the administration of plant extract and silymarin (50mg/kg) the plant extract of Schisandra grandiflora was administered orally at doses of 100mg/kg & 200mg/kg body weight daily for 7 days.Several serum makers, Serum glutamate pyruvate transaminase (SGPT), Serum glutamate oxaloacetate transaminase (SGOT), alkaline phasphatase (ALP), bilirubin total protein was measured to assess the effect of the extract on paracetamol Induced hepatic damage. A comparative histopathological study exhibited almost normal result as compared as control group.