A forty-year-man with a cut injury in his left hand was prescribed intramuscular tetanus toxoid (TT) desensitization injection after intra dermal sensitivity test at Yejin Hospital, Xingtai. The patient felt itching on upper body, dizziness, nausea, vomit, abdominal pain, diarrhea after one hour. On examination, his blood pressure and pulse were respectively 16/11kPa (Kilopascal) and 90 beats/minute, and systemic rash or hives (urticatria) were observed. He was diagnosed as adverse or allergic reaction of tetanus antitoxin. However, the symptoms of the patient were gradually alleviated and improved, and his condition was stabilized thirsty minutes after combined treatment of diphenhydramine (200mg), fluoxetine (10 mg: intramuscular injection), glucose (5%: 1000mg), vitamin C (3.0 g), hydrocortisone (100mg: intravenous infusion). The hives disappeared four hours later. A twenty-two-year-man with an injury in one finger of his right hand was prescribed intramuscular tetanus toxoid (TT) desensitization injection after intra dermal sensitivity test at Yejin Hospital, Xingtai. The patient felt dizziness, nausea, palpitations, breathing with difficulty, itching on upper body, rash or hives (urticatria) several minutes after the booster. On examination, his blood pressure was 16/8kPa (Kilopascal). The patient was diagnosed as adverse or allergic reaction of tetanus antitoxin. Nevertheless, all of the symptoms of the patient were gradually improved and his condition was stabilized thirsty minutes after oxygen administration and combined treatment of adrenaline (0.5 mg: subcutaneous injection), diphenhydramine (200mg), fluoxetine (10 mg), glucose (5%: 1000mg), vitamin C (2.0 g), hydrocortisone (200mg: intravenous infusion). His symptoms disappeared and the hives vanished two hours later.