Objective: The objective of this research was to compare the success rate of treatment between bromocriptine plus clomiphene citrate and bromocriptine among patients of hyperprolactinemic infertility. Materials & Methods: We conducted this comparative research at Allied Hospital Faisalabad from February 2018 to January 2019 on a total of 180 hyperprolactinemic infertility patients. These patients were shortlisted in the age bracket of (20 – 40) years. The study commenced after ethical review committee permission and informed consent of the patients. Results: In the age bracket of 20 years to 40 years the mean age was (29.68 ± 5.45) years. Patients were divided into two groups respectively Group A & B with respective mean age of (28.47 ± 3.22) years and (27.58 ± 4.52) years. We also compared the rate of treatment success among both groups. The success rate in Group – A was reported in 56 patients (62.22%); whereas, Group – B presented a success rate among 73 patients (81.11%). Study Group – B presented a significantly higher success rate of treatment than the patients of Group – A (P-Value 0.0078). Conclusion: Study outcomes speak for the efficacy of bromocriptine plus clomiphene citrate in comparison to sole bromocriptine as a treatment approach to manage hyperprolactinemic infertility. Therefore, the use of bromocriptine plus clomiphene citrate as a treatment option is suggested over the use of bromocriptine alone for the achievement of the majority of pregnancies among women with the hyperprolactinemic infertile profile. Keywords: Prolactin, Pregnancy, Female Infertility, Efficacy, Bromocriptine, Clomiphene Citrate and Bromocriptine