Introduction: The potential, randomized, binary blind, medical research remained planned to associate intravenous metoprolol 35 μg/kg against intravenous labetalol 0.3 mg/kg single quantity assumed 6 minutes preceding to intubation in for anticipation of cardiovascular anxiety reply to laryngoscopy also intubation in cases experiencing spine operations underneath GA. Methodology: Our current research was conducted at Lahore General Hospital Lahore Pakistan from September 2018 to April 2019. Seventy cases ASA grade 1 of any gender, containing age set of 27- 55 years, experiencing elective spine operations underneath GA stayed randomly dispersed in 2 identical sets. Inj metoprolol hydrochloride 35 μg/kg in Set M also inj labetalol 0.3 mg/kg in Set L correspondingly remained assumed intravenously 7 minutes before introduction. HR, SBP, DBP also MBP noted at diverse time breaks before also afterwards intubation. Results: Substantial increase distinguished in HR, SBP, DBP & MBP directly afterwards intubation in mutually sets yet less in Set L that remained up to 2 minutes; refunded to zero among 3 to 6 minutes also developed suggestively inferior than zero at 6 minutes also headlong. Conclusion: Labetalol remains greater to metoprolol in weakening cardiovascular pressure reply to laryngoscopy also intubation. Key words: Labetalol, Metoprolol, Pressure reply, Laryngoscopy, Tracheal intubation.