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Funding acknowledgement: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
A ubiquitin-rhodamine110 assay was used to determine if ZnF-UBD ligands antagonize USP5 deubiquitinase (DUB) activity
activity assay, zinc finger, usp5, fluorescence assay, ubiquitin rhodamine
activity assay, zinc finger, usp5, fluorescence assay, ubiquitin rhodamine
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