Introduction: Nephrotic syndrome is characterized by gross proteinuria, hypo albuminemia, hyperlipidemia, and peripheral edema. The etiology of nephrotic syndrome in adults is complex and ranges from primary glomerulonephritis to secondary forms. Objectives of the study: The main objectives of the study is to find the recent advances and medicines used for nephrotic syndrome in Pakistan. Methodology of the study: This cross sectional study was conducted in BHU Uch Gul Imam District Jhang during January 2019 to July 2019. The data was collected from 100 patients of both genders which was suffering from nephrotic syndrome. The basic purpose of this data is to find and investigate the recent advances and treatments of nephrotic syndrome in Pakistani hospitals. Results: The study group comprised of 100 patients 72 (93.5%) were initial steroid resistant and 28 were late non-responders. Gender distribution showed 49 (63.6%) males and 28 (36.4%) females with a ratio of 1.75. Age range of patients was 1-15 years with a mean of 8.11 +3.58 years. Sixty nine (89.6%) patients underwent renal biopsy. Patients with focal segmental glomerulo sclerosis (FSGS) were least likely to respond to treatment followed by mesangio proliferative glomerulonephritis and minimal change disease. Conclusion: Nephrotic syndrome can increase your child’s risk of infection and blood clots. It always affects both kidneys and usually appears in the early years of your child’s life. Most children with this disorder outgrow it by young adulthood.