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Deliverable 9.2: Specific recommendations regarding implementation of mechanism‐based test strategy for harmonised cumulative risk assessment according OECD, WHO, EFSA and EuroMix Guidance

Authors: Fischer, Benjamin; Schubert, Jens; Rotter, Stefanie; Solecki, Roland;

Deliverable 9.2: Specific recommendations regarding implementation of mechanism‐based test strategy for harmonised cumulative risk assessment according OECD, WHO, EFSA and EuroMix Guidance

Abstract

The purpose of Task 9.2 was to summarise the key objectives and outcomes of the EuroMix WPs, to highlight the findings of Deliverable 9.1 as summarised in the position paper (Rotter, Beronius et al. 2019) and to briefly present the outcome of the four international harmonisation workshops as well as the WHO consultation in Geneva 2019. Building on those achievements, Task 9.2 aims to make recommendations addressing risk managers in the EU, i.e. EU Commission, regarding implementation of a harmonised assessment of combined exposure to multiple chemicals on the one hand and regulatory needs such as improved harmonisation between EFSA, SCoPAFF, OECD and WHO on the other. The present report therefore aims to provide a very brief overview on the EuroMix project by highlighting the most relevant findings and summarising its conclusions for improvement of new guidance documents for risk assessment of combined exposure to multiple chemicals. The report also considers the implementation of the recently published EFSA Guidance on harmonized methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals (EFSA 2019), EFSA Statement – Genotoxicity assessment of chemical mixtures (EFSA 2019) as well as the OECD Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals with regard to future research and development needs (OECD 2018). Further recommendations regarding the EuroMix toolbox are summarised in Deliverable 8.4 “Report with recommendation for OECD and other international organisations”.

Keywords

international harmonization, cumulative risk assessment, research and development needs, recommendations, Guidance, pesticides, combined exposure to multiple chemicals

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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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impulse
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