Ayurveda defines body as something that is constantly going through the process of decay- shiryateitishariram1, here decay indicates gradual ageing of the body. Ageing is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death, the rate and extent of which varies among individuals2. Osteoarthritis (OA) is not only the most common joint disease, but is also one of the major causes of disability in people aged >65 years and is accompanied by co-morbid conditions, increased mortality, and decreased quality of life. One of the major risk factors for OA is ageing3. With the process of ageing all dhatus undergo kshaya, and leads to vataprakopa and the vitiated Vatadosha get lodged in Asthisandhis and give rise to Sandhigatavata. The present clinical work is based on the study of 45 patients of Sandhigatavata (Osteo-arthritis) divided into three Groups A, B and C in terms of the nature of given treatment. Group A patients were prescribed Shamana therapy with Rasnadiguggulu, group B patient were administered Panchamulabaladiksheerbasti in kalabasti schedule of 16 days, group C patients were given Rasnadiguggulu after completion of Panchmulabaladiksheerbasti as per the schedule in group B. Subjective parameters and objective parameters were made out to assess the Clinical response. All group shows statistically highly significant relief in the subjective and objective parameters.