Background: The quick beginning in addition petite period of propofol types it the perfect anesthetic throughout esophagogastroduodenoscopy (EGD). Fentanyl remains regularly exercised in mixture through propofol throughout EGD to deliver the analgesic constituent. The interaction that consequences from joining 2 medicines might remain helpful nevertheless might similarly rise possible for apnea, vomiting, in addition protracted repossession. Our current pilot research remained intended to examination hypothesis that propofol anesthesia offers improved situations than propofol alone throughout EGD in addition to associate occurrence of side effects among 2 methods. Methodology: The current research was conducted at Services Hospital Lahore from July 2018 to April 2019. Our current research remained the IRB accepted, dual blinded, potential, control measured research. 120 agreed cases experiencing EGD remained arbitrarily allocated into 2 Sets. Cases in primary Set established fentanyl 1 μg/kg trailed via propofol 0.78 mg/kg bolus, whereas cases in propofol Set established propofol 2.6 mg/kg bolus. Cases in Set that established fentanyl established half early introduction quantity of propofol in command to minimalize possible for apnea besides hypoventilation owing to interaction among 2 medicines. In equally Sets, added 25 mg propofol boluses remained assumed at 2 minutes intermissions pending passable complexity of anesthesia remained grasped. Propofol distillation remained then underway besides attuned to preserve passable penetration of anesthesia throughout process. The main end point remained excellence of anesthesia by way of regarded through blinded endoscopist. The secondary end points stood occurrence of hypotension, vomiting, nausea, in addition, behind retrieval. Information from 2 Sets stayed associated through Wilcoxon rank trial for main endpoint, through t-test for incessant procedures, in addition through chi square for extents counting hypoxia in addition hypotension. Results: The endoscopists’ assessment scores remained statistically expressively advanced in propofol/fentanyl Set. Fentanyl had the statistically substantial economic consequence on propofol introduction amount. Not any statistically substantial variance among 2 Sets remained originate in other research limitations. Conclusion: The mixture of propofol in addition fentanyl offers improved excellence of anesthesia than propofol alone throughout EGD by not any ostensible extra side belongings.