Supplementary file 1: Supplemental Experimental Procedures. Supplementary file 2: Table S1. Characteristics of the public microarray datasets used in this study. Supplementary file 3: Table S2. MiRNA-level results in integrated analysis of three datasets. Supplementary file 4: Table S3. Differential miRNAs were selected using the LASSO and SVM-RFE algorithms between CRC and ANT. Supplementary file 5: Figure S1. Cross-validation for tuning parameter selection in the LASSO logistical model (A) and SVM-RFE model (B). Supplementary file 6: Table S4. Clinical features for the CRC patients in the testing set GSE29622 and validation set TCGA-COAD. Supplementary file 7: Table S5. Sixty-six consensus target genes were summarized by 4 different target prediction algorithms.