Elaeisguineensis and Khaya senegalensis are two plants used in Africa to treat many bacterial and parasitic diseases. While the data relating to their toxicity are insufficient. This study aimed to determine the toxicity of the aqueous extracts of the leaves of E. guineensis and the stem bark of K. senegalensis. Acute oral toxicity has been evaluated according to OECD guideline 423 at a single dose of 2000 mg/kg body weight body on Wistar rats. After administration of the extracts, the biochemical data and hematological data were evaluated on days 0, 7 and 14. Cytotoxicity of plant extracts was assessed by determining the mortality of Artemiasalina, after exposure for 24 hours at different concentrations of extracts. The results showed that after 14 days of experimentation, no mortality and behavior changes were recorded in Wistar rats. However, the rates Hematocrits decreased significantly with the administration of aqueous extracts of Khaya senegalensis (43.63% ? 1.71 to 38.57% ? 1.27) and Elaeisguineensis (46.90% ? 4.06 at 39.03% ? 3.37). For the Mean Corpuscular Volume, there was an increase between day 0 and day 7 (p<0.05) followed by normalization on day 14 for both extracts. Lethal dose 50 for cytotoxicity were 2.7 mg/ml and 152 mg/ml respectively for K. senegalensis and E. guineensis. These data show that the extracts tested can contribute without risk to the management of parasitic diseases, when used at the doses tested.