Introduction- Coronary artery disease is one of the most common amongst the heart diseases. It occurs when the blood supplying arteries to the heart becomes very narrow and hard due to the plaque buildup. Therefore, the single or dual antiplatelet drug therapy (clopidrogrel + Aspirin or clopidogrel alone) is widely accepted and challenging strategy in the patients with Coronary artery disease to reduce myocardial infarction and stent thrombosis. The outcomes and prescribing patterns associated with these therapies are observed in this study. Method- The retrospective study was conducted for a period of 8 months in which 150 case reports/ prescriptions with single anti-platelet therapy (clopidrogrel) or Dual anti-platelet therapy (clopidogrel + Aspirin) were collected and noted in a data form. The data obtained is used to observe the prescribing patterns and their outcomes. Results- The data was collected from 150 patients in Medical intensive care unit (MICU), Critical intensive care unit (CICU), Intensive care unit (ICU), and general ward. The male to female ratio was found to be 103 (68.66%): 47 (31.33%). The usage of Single Anti-Platelet Therapy was found to be quite lesser than Dual Anti-Platelet Therapy. The patients with Dual anti-platelet therapy were at the higher risk of life threatening bleeding and ischemic complications but the use of dual anti-platelet therapy has found to be beneficent in reducing the myocardial infarction and stent thrombosis. The choice of dual anti-platelet therapy or single anti-platelet therapy depends upon the duration of patients, their profile, risk, benefits and management therapy. Conclusion- The main focus of our study was the prescription of Aspirin and Clopidogrel both as single drug and in combination, the medication given while admission of patient in the hospital were 20, (13.33%) of Aspirin, 7, (4.66%) of Clopidogrel and 25, (16.66%) Aspirin + Clopidogrel and medication given while discharging of patient in the hospital were 46, (37.70%) of Aspirin, 25, (20.49%) of Clopidogrel and 51, (41.80%) Aspirin + Clopidogrel 65.33% were Other Miscellaneous drugs.