Statement of the problem: Effectiveness of oral sucrose solution on pain perception among infants receiving immunization injection in Ashwin Hospital at Coimbatore. Objectives: a) To assess the level of pain among infants receiving immunization after administering the oral sucrose solution. b) To assess the effectiveness of oral sucrose solution on pain perception among experimental group and control group infants. c) To find out the association between post test level of pain with selected demographic variables among experimental group infants. d) To find out the association between post test level of pain perception with selected demographic variables among control group infants. Methodology:The research design used was Quasi Experimental Post test only Design. Sample size was 60 infants who was receiving immunization, in which 30 were in experimental group and 30 were in control group. The samples were selected by using convenient sampling method. NIPS pain scale was used for the data collection which was a standardized tool. The data collection tool was valued by four experts, reliability was established by Karl pearsons correlation method. The main study was conducted in Ashwin hospital at Coimbatore. The data collected were tabulated, analyzed and interpreted by using micro soft excel 2007. Results:Inferential and descriptive statistics used to evaluate the effectiveness of the oral sucrose solution for pain perception among infants receiving immunization injection. Student t test was used to find out significant difference between experimental and control group pain perception score. The ?t? test score was 19.54. x2 used to assess the association between the experimental and control group with demographic variables of the infants. in experimental group after the sucrose administration majority 21 (70%) of infants had mild pain, were as in control group majority 29 (97%) of infants had severe pain. In experimental group there was no significant relationship between the demographic variables and sucrose solution on pain perception. In control group there was no significant relationship between the demographic variable and sucrose solution on pain perception. Conclusion:The findings of the study revealed that 24% sucrose administration among infants who are undergoing immunization was independently effective in reducing pain perception.