What is a disease, what causes disease and why some people fall ill and others don\'t, are the questions we have all asked ourselves many times. Different branches of science and different medical systems have tried to answer these questions, but the right answer is still missing. In Western medicine, the causes have been looked for among different pathogens, i.e. external causes and genetic heritage or inborn ?mistakes?in the system which result in a disease. Furthermore, there are autoimmune diseases, but there is no answer what exactly causes autoimmune reaction or, to put it differently, why our body ?raises its hand?to itself. While in Ayurveda there is clear mentioning of the cause for above mentioned diseases. Ayurveda has classified the causes of disease into three main categories: AsatmendriyarthaSamyoga 2.Prajnaparadha and 3.Parinama (Kaala) According to Ayurveda, these three main causes of disease enable different kinds of diseases to manifest. Firstly, they lead to the imbalance of body /or mind by vitiation the Tridosha. The consequence of the imbalance is a disturbance of the basic biological principles, which makes the body prone to disease no matter whether it is an infection, manifestation of hereditary inclination or autoimmune reaction. Hence an attempt has been made in this paper to understand the concept of Auto Immune Disorder in terms of Ayurveda. How Auto immune can be correlated to Ama and role of TrividhaAyatana as triggering factor in causing Ama (Sama) /Auto immune disorder.