Aim. Number of drug addicted patients with chronic odontogenic osteomyelitis of the jaws is increasing year by year. The aim of this work was to study changes in on microlymph flow indicators in drug addicted patients in the course chronic odontogenic osteomyelitis treatment. Materials and methods. Assessment of tissue blood flow in gingival mucosa in patients with chronic osteomyelitis was performed using Laser doppler flowmetry. All patients were divided into two groups: a treatment group and a control group. Sequestrectomy was performed to the patients from the treatment group with a bone defect closed with a concomitant use of PRP gel and FRP membranes. The same surgery was performed to patients from control group with closing a bone defect with iodoform tampon. Results. During the study it was revealed that sequestrectomy with use of PRP gel and FRP membranes leads to rapid decrease in local postoperative inflammatory reactions, improvement of venous outflow and better functioning of microvessels endothelium, and, all in all, to optimization of the tissue healing process in drug addicted patients with chronic odontogenic osteomyelitis. Keywords: odontogenous osteomyelitis of the jaws of drug-addicted, combination treatment, PRP-gel and FRP-mebrane, flowmetry, lymph flow.