Introduction:Rheumatoid arthritis is a chronic systemic inflammatory autoimmune disease, usually involving peripheral joints in a symmetric distribution. Lipids contribute to synovitis in RA through participation in the arachidonic acid pathway within joint space. Aims &Objectives:To study lipid profile along with different atherogenic indices among RA patients & to compare it with healthy matched controls Materials & Methods:This study conducted in the Department of Biochemistry, GGH, KurnoolMedical college, with 25 diagnosed cases of RA and 25 controls over six months Results:In RA cases, females outnumbered males, around 76% of cases are females.The present study shows that 37.5% of RA cases were of the age group of 31-40Yr,32% of the RA cases were of 20-30 Years of age, 28% of RA cases were of age group 41-50 & 6.5% of RA cases were of age 51-60Yrs. A higher index implies an increased cardiovascular risk, and lowering this ratio has shown decrease this risk. Discussion:Total cholesterol, Triglycerides VLDL &LDLamong increased, HDL cholesterol decreased among RA study group compared to the control group Conclusion:The present study showed that RA predominantly found among the middle-aged female population. Patients with RA have significantly lower values of HDL compared to controls10. Significantly higher values of other parameters of lipid profile found among RA patients. Higheratherogenic indices indicate higher cardiovascular risk among RA patients.