This record comprises the main supplement to study 10.1101/2021.08.11.455982. Contained in the archive identified by this record are the following files: SUPPLEMENTARY_METHODS.pdf contains an extended description of the methods of the study, including external links to raw, intermediate, and result data st[1-5]_* supplementary tables referenced in the main manuscript body of the study *.zip files contain intermediate data archives referenced in the supplementary methods, *.txt files with the same names list the contents of the zip files go-basic.obo is an unmodified copy of the Gene Ontology (in OBO format) as used in this study NOTE 1: this record contains additional references (related identifiers) that identify all other data and source code used in this study NOTE 2: for this record and all related records, the authors, their affiliations and their respective funding as relevant to this project are identified in the main manuscript, whose contents take precedence over equivalent metadata fields in supplementary records.