The aim of this paper is to present a methodological approach to estimating technological process in the warehouse complex of the transport and logistics centers with respect to their efficiency. It was determined that one of the main directions of modern transport policy is the transition to transport logistics in the transport and logistics system, which allows us to provide comprehensive services to consumers of transport services, creating conditions for the development of combined transport, reducing the harmful influence on the environment. It is established that in order to carry out the successful implementation of the entire complex of works and reduce the cost of operations in the transport and logistics centers, as an important component of it, it is necessary to implement transport and technological processes, which must be based on progressive techniques and advanced methods. While constructing a mathematical model of an object, it was taken into account that the value of the general criterion of effectiveness depends on the values of the characteristics of the criteria of the effectiveness of the active elements of the system. The technological process of functioning of the warehouse complex of the transport and logistics centers, which is proposed in this paper, allows us to see the whole chain of operations from the moment of arrival of the vehicle with the load to the warehouse until the moment the consignment is shipped to the recipient. The approach to determine the efficient organization of the work of the warehouse complex of the transport and logistics center, according to the criterion, includes the total costs affected by: the intensity of the types cargo flows, the cost of one unit work and one hour work of one worker, the time of execution of the operation, and the amount of resources involved to perform each operation. The analytical models of determination of the estimation parameter are developed. In order to obtain the most reliable data on changes in the parameters of the warehouse process it has been determined the required number of observations be established . Based on the analysis of the order flow parameters of most transport and logistics centers of Ukraine, it has been found that the intensity of the input, internal and output flow of cargo is distributed according to the exponential law. This conclusion was confirmed by an appropriate level of confidence. The experiment, conducted in accordance with the principle of constructing a full-factor plan for the experiment, obtained the results of research on the proposed criterion for determining the efficient organization of the transport and logistics centers warehouse complex for three variants. Relying on the basic data regression models (linear and power) were constructed. An analysis of these models shows that the regression model in linear form with non-zero coefficients is the most adequate one, since the value of the indicator R² is the largest and it is equal to unity. On the received models the values of the criterion of efficiency are defined as total costs, for each variant. On the basis of the received changes in total costs for the organization of the warehouse complex, significant influence of the intensity of the incoming flow of goods has been identified, which in turn requires higher expenses of resources in the zone of acceptance of goods.