The purpose of this paper is multifold: 1) to substantiate the topicality of the problem solution concerning optimal assignment of vehicles to municipal routes for auto-transport enterprises (ATE) in the city of Dnipro. 2) to present technological and economic evaluation of DATP 11255 PJSC enterprise, 3) to provide an overview of the available models to assign buses to routes with the determination of their sphere of use, specifying their key advantages and disadvantages, and 4) to propose a model for optimal assignment of buses to the routes where target function is represented by maximization of ATE income, and the restriction is represented by non-exceedance of maximum admissible values of traffic interval and coefficients of bus capacity use. Passenger flow in terms of DATP 11255 PJSC routes during morning rush hour has been studied by means of table method. Basic technical-operational and economic parameters of the operation of DATP 11255 PJSC routes have been evaluated. Microsoft Excel SOLVER add-in has been applied to obtain optimal assignment of bus departures. The application value of the study is that it will make it possible to: 1) increase DATP 11255 PJSC income by 2.62 times (from 462.8 UAH/hour up to 1 211.8 UAH/hour); 2) improve quality of transportation process owing to the reduced maximum coefficient of the bus capacity use; and 3) ensure non-exceedance of maximum admissible bus traffic interval.