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FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF ABACAVIR

Authors: Amatul Kabeer, Dr. Shaik Shabbeer, Dr. Vivek V. Byahatti, Dr. P. Polireddy;

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF ABACAVIR

Abstract

The aim of the present study was to develop Abacavir controlled release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Carbopol974P, Xanthan Gum and HPMC K 15M were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Cars Index, Hauser’s Ratio, Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F5 showed better and desired drug release pattern i.e., 99.16 % in` 12 hours. It contains the Xanthan Gums polymer. It followed peppas order release kinetics. Key Words: Abacavir, Carbopol974P, Xanthan` Gum and` HPMCK` 15M, Controlled` release tablets.

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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