Guillain-Barre Syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy (AIDP) caused generally by autoimmune response after certain infections. According to Ayurveda, it can be correlated withVatvyadhi-Sarvangaghata. A 40 years old female patient diagnosed with GBS was presented with quadriplegia and severe muscle wasting. EMG-NCV showed demyelinating sensorimotor polyneuropathy. Patient was admitted with the Ayurvedic diagnosis of Vatvyadhi-Sarvangaghata. She was given unique Ayurvedic treatment protocol including Abhyanga, Nasya, ShashtiksaliPindasweda, Matrabastiand internally Ashwagandha Ghrita and Ashwagandha-ShatavariKshirpak. Patient was admitted in our Institute for 90 days. On discharge,patient was able to walk and stand without support, do regular activity without support and had weight gain of 11 Kg. She was happy with the recovery. This case report gives us confidence and more understanding of rare AnuktaVyadhi like GBS. This also signifies importance of Ayurvedic Nidan and Gunavichar in the treatment of such diseases. This also shows the importance of Ayurvedic treatment where Modern medicine is ineffective.