The multi-worlds interpretation of quantum mechanics, starting from the realism, opposes the reduction of wave function in Copenhagen interpretation and aims to search for what happens after the measurements and to seek the essence of wave function. Different from the emphasis for consciousness of observers during the measurements in Copenhagen interpretation, the multi-world interpretation inherits the determinism in the aspects of methodology, epistemology, as well as ontology. This paper aims to discuss the concepts of realism and determinism in themulti-worlds interpretation from the viewpoint of methodology, epistemology, as well as ontology and to demonstrate that it transcends the traditional determinism.