Background: Stasis dermatitis is a common clinical manifestation present with varicose vein, skin changes such as dermatitis hyperpigmentation, lipodermatosclerosis and chronic leg ulcers. Cellulitis occurs when the bacteria enter the skin and spread which results in redness, painful swelling or warmth. Case Presentation: A 52 years old male patient was admitted in a Tertiary care hospital at Thiruvallur with the chief complaints of swelling and open sore for two weeks and itching for about 10 days and redness since 4 days. Later he developed skin lesions and cracking skin in both the legs with exudation. The patient was diagnosed to have stasis dermatitis with cellulitis. The patient was treated with topical applications and antibiotics to improve the clinical condition. Conclusion: The patient was treated with appropriate drug therapy with proper counselling sessions regarding disease, drugs and lifestyle modifications.The pharmacist plays an important role in analyzing the case study in order to provide excellence in clinical outcomes and to improve the patient?s quality of life.