1-PlackettBurman-Input&Output.zip: Included 13 inputs and corresponding outputs files of T2Well/ECO2N based on the Plackett-Burman design. The calculation of mass flow rate from output files and all simulation results were listed in two excel files (PB-9Ffactors-13runs-MassFlowRate.xlsx and PB-9Factors-13runs-Results.xlsx), respectively. The JMP file for Plackett-Burman design was also included. 2-BoxBehnken-Input&Output.zip: Included 54 inputs and corresponding outputs files of T2Well/ECO2N based on the Box-Behnken design. The calculation of mass flow rate from output files and all simulation results were listed in two excel files (BB-6factors-54Runs-MassFlowRate.xlsx and BB-6factors-54runs-Results.xlsx), respectively. 3-NonDesignPoint-Input&Output.zip: Included 30 inputs and corresponding outputs files of T2Well/ECO2N based on randomly selected non-design points. The calculation of mass flow rate from output files and all simulation results were listed in two excel files (NonDesignPoint-30Runs-MassFlowRate.xlsx and NonDesignPoint-30Runs-Results.xlsx), respectively. The JMP file for Box-Behnken design and non-design points was also included. 4-MaxMinOfWRModel-Input&Ouput.zip: Included 6 inputs and corresponding outputs files of T2Well/ECO2N based on sensitivity indicators. The simulation results and the values of sensitivity indicators were listed in two excel files (MaxMin-Results.xlsx and SettingBaseOnJMP-SensitivityIndicator.xlsx), respectively. 5-MatlabCode-MultiOptimization.zip: the two kinds of optimization analyses were integrated into two folders. In the 4factors-3obj-NSGA-II, the MatLab code for optimizing four input factors and its results were listed. In the 3factors-Fixk-NSGA-II, the MatLab code for optimizing three input factors with considering k uncertainty and specific field conditions and its results were listed.